チームリーダー

牧野嶋 秀樹

Hideki Makinoshima

hmakinoshima.jpg

「がん」は、治療がとても難しい深刻な病気だと思う。予防や初期に発見することが、「がん」への対策で一番重要と個人的には考えている。ただ、現実問題として、がんに罹患しても長く生きたいと希望を持たれる方がいる。そのような患者さんのために、がん対策の一助となるような「がんの代謝研究」をここ鶴岡で展開したい。研究を開始した頃は、知的好奇心から生じる自分の興味を追求する研究が一番重要だった。研究キャリアを重ねるにつれ、「がん」により生じる様々な社会問題を解決できれば良いと今は考えている。

 

研究業績

1. Difference in the relative biological effectiveness and DNA damage repair processes in response to proton beam therapy according to the positions of the spread out Bragg peak.
Hojo H, Dohmae T, Hotta K, Kohno R, Motegi A, Yagishita A, Makinoshima H, Tsuchihara K, Akimoto T.
Radiat Oncol. 2017 Jul 3;12(1):111. doi: 10.1186/s13014-017-0849-1.

2. Mycobacterium tuberculosis protease MarP activates a peptidoglycan hydrolase during acid stress.
Botella H, Vaubourgeix J, Lee MH, Song N, Xu W, Makinoshima H, Glickman MS, Ehrt S.
EMBO J. 2017 Feb 15;36(4):536-548. doi: 10.15252/embj.201695028. Epub 2017 Jan 5.

3. Genomic Profiling of Large-Cell Neuroendocrine Carcinoma of the Lung.
Miyoshi T, Umemura S, Matsumura Y, Mimaki S, Tada S, Makinoshima H, Ishii G, Udagawa H, Matsumoto S, Yoh K, Niho S, Ohmatsu H, Aokage K, Hishida T, Yoshida J, Nagai K, Goto K, Tsuboi M, Tsuchihara K.
Clin Cancer Res. 2017 Feb 1;23(3):757-765. doi: 10.1158/1078-0432.CCR-16-0355. Epub 2016 Aug 9.

4. [Therapeutic strategies targeting cancer--specific metabolism].
Makinoshima H, Owada S, Esumi H.
Nihon Rinsho. 2015 Aug;73(8):1296-301. Review. Japanese.

5. Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma.
Makinoshima H, Takita M, Saruwatari K, Umemura S, Obata Y, Ishii G, Matsumoto S, Sugiyama E, Ochiai A, Abe R, Goto K, Esumi H, Tsuchihara K.
J Biol Chem. 2015 Jul 10;290(28):17495-504. doi: 10.1074/jbc.M115.660498. Epub 2015 May 28.

6. Single-cell analysis of lung adenocarcinoma cell lines reveals diverse expression patterns of individual cells invoked by a molecular target drug treatment.
Suzuki A, Matsushima K, Makinoshima H, Sugano S, Kohno T, Tsuchihara K, Suzuki Y.
Genome Biol. 2015 Apr 3;16:66. doi: 10.1186/s13059-015-0636-y.

7. Aberrant transcriptional regulations in cancers: genome, transcriptome and epigenome analysis of lung adenocarcinoma cell lines.
Suzuki A, Makinoshima H, Wakaguri H, Esumi H, Sugano S, Kohno T, Tsuchihara K, Suzuki Y.
Nucleic Acids Res. 2014 Dec 16;42(22):13557-72. doi: 10.1093/nar/gku885. Epub 2014 Nov 6.

8. Therapeutic priority of the PI3K/AKT/mTOR pathway in small cell lung cancers as revealed by a comprehensive genomic analysis.
Umemura S, Mimaki S, Makinoshima H, Tada S, Ishii G, Ohmatsu H, Niho S, Yoh K, Matsumoto S, Takahashi A, Morise M, Nakamura Y, Ochiai A, Nagai K, Iwakawa R, Kohno T, Yokota J, Ohe Y, Esumi H, Tsuchihara K, Goto K.
J Thorac Oncol. 2014 Sep;9(9):1324-31. doi: 10.1097/JTO.0000000000000250.

9. Epidermal growth factor receptor (EGFR) signaling regulates global metabolic pathways in EGFR-mutated lung adenocarcinoma.
Makinoshima H, Takita M, Matsumoto S, Yagishita A, Owada S, Esumi H, Tsuchihara K.
J Biol Chem. 2014 Jul 25;289(30):20813-23.

10. Intracellular concentrations of 65 species of transcription factors with known regulatory functions in Escherichia coli.
Ishihama A, Kori A, Koshio E, Yamada K, Maeda H, Shimada T, Makinoshima H, Iwata A, Fujita N.
J Bacteriol. 2014 Aug;196(15):2718-27. doi: 10.1128/JB.01579-14. Epub 2014 May 16.

11. Identification of a lung adenocarcinoma cell line with CCDC6-RET fusion gene and the effect of RET inhibitors in vitro and in vivo.
Suzuki M, Makinoshima H, Matsumoto S, Suzuki A, Mimaki S, Matsushima K, Yoh K, Goto K, Suzuki Y, Ishii G, Ochiai A, Tsuta K, Shibata T, Kohno T, Esumi H, Tsuchihara K.
Cancer Sci. 2013 Jul;104(7):896-903. doi: 10.1111/cas.12175. Epub 2013 May 12.

12. PTPRZ1 regulates calmodulin phosphorylation and tumor progression in small-cell lung carcinoma.
Makinoshima H, Ishii G, Kojima M, Fujii S, Higuchi Y, Kuwata T, Ochiai A.
BMC Cancer. 2012 Nov 21;12:537. doi: 10.1186/1471-2407-12-537.

13. Human umbilical cord-derived mesenchymal stromal cells differentiate into functional Schwann cells that sustain peripheral nerve regeneration.
Matsuse D, Kitada M, Kohama M, Nishikawa K, Makinoshima H, Wakao S, Fujiyoshi Y, Heike T, Nakahata T, Akutsu H, Umezawa A, Harigae H, Kira J, Dezawa M.
J Neuropathol Exp Neurol. 2010 Sep;69(9):973-85. doi: 10.1097/NEN.0b013e3181eff6dc.

14. M. tuberculosis intramembrane protease Rip1 controls transcription through three anti-sigma factor substrates.
Sklar JG, Makinoshima H, Schneider JS, Glickman MS.
Mol Microbiol. 2010 Aug;77(3):605-17. doi: 10.1111/j.1365-2958.2010.07232.x. Epub 2010 Jun 1.

15. Unique multipotent cells in adult human mesenchymal cell populations.
Kuroda Y, Kitada M, Wakao S, Nishikawa K, Tanimura Y, Makinoshima H, Goda M, Akashi H, Inutsuka A, Niwa A, Shigemoto T, Nabeshima Y, Nakahata T, Nabeshima Y, Fujiyoshi Y, Dezawa M.
Proc Natl Acad Sci U S A. 2010 May 11;107(19):8639-43. doi: 10.1073/pnas.0911647107. Epub 2010 Apr 26.

16. Pancreatic cancer cells activate CCL5 expression in mesenchymal stromal cells through the insulin-like growth factor-I pathway.
Makinoshima H, Dezawa M.
FEBS Lett. 2009 Nov 19;583(22):3697-703. doi: 10.1016/j.febslet.2009.10.061. Epub 2009 Oct 27.

17. Site-2 proteases in prokaryotes: regulated intramembrane proteolysis expands to microbial pathogenesis.
Makinoshima H, Glickman MS.
Microbes Infect. 2006 Jun;8(7):1882-8. Epub 2006 Apr 27. Review.

18. Regulation of Mycobacterium tuberculosis cell envelope composition and virulence by intramembrane proteolysis.
Makinoshima H, Glickman MS.
Nature. 2005 Jul 21;436(7049):406-9.

19. Classification and strength measurement of stationary-phase promoters by use of a newly developed promoter cloning vector.
Shimada T, Makinoshima H, Ogawa Y, Miki T, Maeda M, Ishihama A.
J Bacteriol. 2004 Nov;186(21):7112-22.

20. A unifying model for the role of polyamines in bacterial cell growth, the polyamine modulon.
Yoshida M, Kashiwagi K, Shigemasa A, Taniguchi S, Yamamoto K, Makinoshima H, Ishihama A, Igarashi K.
J Biol Chem. 2004 Oct 29;279(44):46008-13. Epub 2004 Aug 23.

21. Growth phase-coupled alterations in cell structure and function of Escherichia coli.
Makinoshima H, Aizawa S, Hayashi H, Miki T, Nishimura A, Ishihama A.
J Bacteriol. 2003 Feb;185(4):1338-45.

22. Fractionation of Escherichia coli cell populations at different stages during growth transition to stationary phase.
Makinoshima H, Nishimura A, Ishihama A.
Mol Microbiol. 2002 Jan;43(2):269-79.